中医整体观对原发性高血压、糖尿病、高脂血症发生发展研究的启示(英文)

Enlightenment of the holism in traditional Chinese medicine to research of onset and development of essential hypertension,diabetes and hyperlipemia

目的:从中医整体观的角度探索高血压、糖尿病及高脂血症在发病机制上的相关性。资料来源:应用计算机检索Medline1985-01/2004-12关于高血压、糖尿病、高脂血症发病机制的文章,检索词“hypertension,diabetes,hy-perlipemia,pathogenesis”,并限定语言种类为English。同时检索中国期刊全文数据库1990-01/2004-12关于高血压、糖尿病、高脂血症发病机制的文章,限定文章语言种类为中文,检索词“高血压、糖尿病、高脂血症、发病机制”。资料选择:对资料进行初审,选取高血压病、糖尿病、高脂血症的中医病因病机及现代医学发病机制的文献。纳入标准为①随机对照临床试验,采用单盲、双盲或非盲法。②非随机对照试验。③前后对照试验研究。④专著中的章节。排除标准:排除重复性研究。资料提炼:共收集到28篇关于高血压病、糖尿病、高脂血症的中医病因病机及现代医学发病机制的文章,其中12篇符合纳入标准。排除的16篇均为重复性文章。资料综合:对12篇关于中医及现代医学对高血压病、糖尿病、高脂血症的发病机制的认识文章进行分析,并从分子生物学的角度提示这3种疾病的内在联系。结论:设想把这3种疾病当成一个整体来加以研究。把高血压、高血糖、高血脂看成是这一整体的不同表现形式,或者是这一整体的不同发展过程,

OBJECTIVE:According to the holism in traditional Chinese medicine(TCM) theory,this manuscript explores the relativity of pathogenesis among hypertension,diabetes and hyperlipemia. DATA SOURCES:We applied computer to search articles in English on pathogenesis of hypertension,diabetes and hyperlipemia in Medline between January 1985 and December 2004 by words “hypertension,diabetes,hyperlipemia,pathogenesis'.Besides,we also used computer to search articles in Chinese on pathogenesis of hypertension,diabetes and hyperlipemia in Chinese magazine full text database between January 1990 and December 2004 by words “hypertension,diabetes,hyperlipemia,pathogenesis'. STUDY SELECTION:Primarily,articles on pathogenesis of hypertension,diabetes and hyperlipemia were selected in TCM and modern medicine respectively.Accepted standard were:①Random control clinic test with methods of single blind,double blind or no blind;②Nonrandom control test;③Fore-and-aft control test;④Chapter in monograph.Eliminated standard:repeated research. DATA EXTRACTION:Totally 28 articles on pathogenesis of hypertension,diabetes and hyperlipemia were found in TCM and modern medicine,however,12 articles were selected according to accepted standard,and 16 articles were eliminated due to repeated content. DATA SYSTHESIS:Totally 12 selected articles were analyzed on pathogeneses of hypertension,diabetes and hyperlipemia in TCM and modern medicine,and hinted internal affiliation of these three diseases from view of molecular biology. CONCLUSION:These three diseases can be regarded as a whole entity for study.High blood pressure,high blood sugar and high lipemia could be treated as different forms of the entity or in different developing courses of the whole.In a certain course it might present as one of the forms specifically.It might manifest high blood pressure mainly in clinic,or high blood sugar,or high lipemia,also several forms at the same time.It will be beneficial to take the holism and visceral theory in TCM for reference in research of modern medicine.