治疗心脑血管疾病中成药微量和常量元素含量与疗效的模糊分类法则(英文)

Contents of trace and constant elements and therapeutic effects of Chinese patent medicine on cardio-cerebral vascular disease:fuzzy classified principle

背景:研究发现,中成药中的微量元素对药效和结构分析具有重要作用,以无机微量元素的角度来进一步研究中药的药效和有效成分逐渐形成一个新的课题。中药微量、常量元素与疗效关系的模糊分类研究是从微量元素整体角度讨论药物的微量元素功能作用,更科学的研究中药中的微量元素整体协调作用。目的:检测21种治疗心脑血管疾病中成药物中微量、常量元素的含量;运用模糊分类方法研究药物微量、常量元素与疗效的相关性,以期为中成药的质量评价提供一种新的方法。设计:以各种中成药为研究对象,验证性观察研究。单位:一所大学的化学教研室和一所化学工业集团公司总医院一院的心血管内科。材料:选择临床常用的治疗心脑血管疾病的中成药21种,地奥心血康胶囊、血栓心脉宁胶囊、山海丹胶囊、步长脑心通胶囊、利脑心胶囊、心脑素胶囊、利心丸、速效救心丸、心宝丸、银杏叶片、复方丹参片、牛黄降压丸、脑塞通片、强力天麻杜仲丸、通塞脉片、通脉宁心冲剂、脉通胶囊、复方银杏胶丸、大活络丹、冠心苏合胶囊、消栓通络胶囊。方法:采用湿法消解法处理样品,用原子吸收分光光度法测定21种中成药物中钠、钙、镁、钾、铁、镍、铬、铜、锌、锰10种微量、常量元素的含量;

BACKGROUND:It is discovered that trace elements in Chinese patent medicine play an important role in pharmaceutical efficacy and structural analysis.A new topic has been formed gradually in a further research on pharmaceutical efficacy and effective components of Chinese patent medicine in the view of inorganic trace elements.The fuzzy classified study on the interrelationship between trace and constant elements of Chinese herbs and therapeutic effects is to discuss the trace-element action of drugs in the holistic aspect of trace element and research rather scientifically the holistic coordination among trace elements in Chinese herbs. OBJECTIVE:To determine the contents of 21 kinds of trace and constant elements in Chinese patent medicines in the treatment of cardio-cerebral vascular disease.To study with fuzzy classified method the interdependence between trace,constant elements of drugs and therapeutic effects so as to provide a new approach for the quality evaluation of Chinese patent medicine. DESIGN:Testified observed study based on various Chinese patent medicines. SETTING:Chemistry teaching-research room in a university and department of cardiology in a general hospital of a chemical industrial group corporation. MATERIALS:Twenty-one kinds of common Chinese patent medicines for the treatment of cardio-cerebral vascular diseases in clinic,namely di'ao xinxuekang capsule(DXK),xueshuan xinmaining capsule(XMN),shanhaidan capsule(SHD),buchang naoxintong capsule(NXT),linaoxin capsule(LNX),xinnaosu capsule(XNS),lixin wan(LXW), suxiao jiuxin wan (SJX), xin bao wan(XBW), yinxingye pian(YXY),fufang danshen pian(DSP), niuhuang jiangya wan(NHJY),naosaitong pian(NST),qiangli tianma duzhong wan(TDW),tongsaimai pian(TSM),tongmai ningxin infusion(TMNX), maitong capsule(MTC),fufang yinxing wan(YXW),da huoluo dan(DHL),guanxin suhe capsule(GXSH) and xiaoshuan tongluo capsule(XSTL). METHODS:Wet digestion was used to manage samples,atomic absorption spectrophotometric method(AAS) method was used to determine the contents of 10 kinds of trace and constant elements in 21 Chinese patent medicines,namely Na,Ca,Mg,K,Fe,Cr,Ni,Cu,Zn and Mn.Data range method was applied for the standardized management of statistical indexes of various element contents in relevant drugs,dotprod(U,V) method was used to measure correlation coefficient(r) among the classified objects so as to determine fuzzy matrixes in universe.The interrelationship was analyzed between the contents of trace elements of various Chinese medicines and pharmaceutical efficacy.By the analysis of fuzzy matrixes in universe,it was to evaluate firmly on the efficacy similarity of various kinds of Chinese patent medicines with quantitative indexes. MAIN OUTCOME MEASURES:①Results of element contents;②Results of fuzzy cluster analysis on elements. RESULTS:The standardized management of statistical indexes was carried on the contents of Na,Ca,Mg,K,Fe,Cr,Ni,Cu,Zn and Mn in various drugs to determine correlation coefficient(r) among the classified objects so as to determine fuzzy matrixes in universe.When(r)=0.55,there were 9 kinds of drugs similar in cluster,namely xueshuan xinmaining capsule,buchang naoxintong capsule,lixin wan,xin bao wan,qiangli tianmai duzhong wan,tongsaimai pian,maitong capsule,da huoluo dan and xiaoshuan tongluo capsule.When(r)=0.65,there were 6 kinds of drugs similar in cluster,namely buchang naoxintong capsule,xin bao wan,qiangli tianmai duzhong wan,tongsaimai pian,maitong capsule and xiaoshuan tongluo capsule.When(r)=0.87,there were 2 kinds of drugs similar in cluster,namely buchang naoxintong capsule and xin bao wan. CONCLUSION:It is indicated in the research that the drugs are in rich of trace and constant elements.The larger the correlation coefficient of drugs is,the more similar the pharmaceutical efficacy is.It is discovered the close interrelationship of the trace and constant elements in drugs with their pharmaceutical efficacy.In this research,fuzzy classified method is used to discuss,in the view of trace elements,the similarity of quantitativ