奥沙利铂联合亚叶酸钙、氟尿嘧啶治疗晚期胃癌

Oxaliplatin in combination with calcium folinate and fluorouracil for treatment of advanced gastric cancer

目的:评价奥沙利铂联合氟尿嘧啶(5 Fu)、亚叶酸钙(CF)治疗晚期胃癌的疗效及安全性。方法:奥沙利铂(OXA) 130mg/m2 ,静脉滴注(静滴) 2h ,第1天;亚叶酸钙2 0 0mg静滴1h ,第1～5天;5 Fu 35 0mg/m2 静滴4h ,第1～5天;每3周重复一周期,连用2周期后评价疗效。结果:观察2 8例,其中CR 1例,PR 11例,SD 10例,PD 6例,总有效率4 2 .9%。主要不良反应为白细胞下降、恶心呕吐及周围神经毒性。结论:奥沙利铂联合化疗治疗晚期胃癌疗效较好,且不良反应小。

Objective:To evaluate the effect and safety of oxaliplatin(OXA) combined with calcium folinate(CF) and fluorouracil(5-Fu) regimen for patients with advanced gastric cancer.Methods:OXA 130 mg/m^2 (2 hours infusion on the first day),CF 200 mg/m^2 (1 hour infusion for 5 days) and 5-Fu 350 mg/m^2(4 hours infusion on the first day) were administered and the regimen was repeated every 3 weeks.The efficacy was evaluated after two repeated cycles were completed.Results:Twenty-eight patients were included in the study.One patient achieved CR,11 PR,10 SD and 6 PD.The overall response rate was 42.9%.The main adverse effects were bone marrow suppression,nausea,vomiting and neurosensory toxicity.Conclusions:OXA-CF-5-Fu regimen is highly effective for treatment of advanced gastric cancer with mild toxicity.