米诺环素作为牙周手术根面处理剂的临床研究

Clinical study of minocycline administrated as a root conditioner for periodontal surgery

目的:探讨牙周翻瓣术后用米诺环素作为根面处理剂的临床效果。方法:将23名有中到重度牙周炎需做牙周翻瓣术的患者随机分成两组:对照组仅进行牙周翻瓣术,不做根面处理。实验组在牙周翻瓣术后,用米诺环素处理根面。观察两组术后3d和7d的术区反应及基线时、术后8周及12周的菌斑指数、牙龈指数、探诊出血、探诊深度的动态变化。结果:术后3d,实验组的术后反应显著轻于对照组(P<0.01)。与基线检查时相比,两组菌斑指数,牙龈指数,探诊出血及探诊深度均有显著改善。除8周时,实验组的探诊出血率显著低于对照组(P<0.05)外,两组之间的牙周指数并无显著性差异(P>0.05)。结论:米诺环素作为根面处理剂,能迅速减轻术后牙周组织的炎症反应,促进创口愈合。

AIM:To evaluate the clinical effect of minocycline as a root conditioner for periodontal surgery.METHODS:23 patients suffering from moderate to advanced periodontitis were randomly assigned to two groups: The control group was treated by a flap procedure and without root conditioning,while the test group was treated by a flap procedure and with minocycline administrated as root conditioner.Three and 7 days after operation, wound healing conditions were evaluated between the two groups.Moreover,clinical periodontal parameters including plaque index (PLI),gingival index (GI),bleeding on probing (BOP) and probing depth (PD) were recorded at baseline,8 and 12 weeks after operation.RESULTS:Three days after operation,there was significant difference in wound healing conditions between the two groups( P <0.01).Control and test groups showed significant improvement in PLI,GI,BOP and PD when compared with those of the baseline examination.According to the periodontal parameters,there was no significant difference between the two groups during the observation period except that the ratio of BOP in the test group were significantly lower than that in the control group 8 weeks after operation( P <0.05).CONCLUSION:As a root conditioner,minocycline could help to relieve the periodontium inflammation after periodontal surgery and enhance the wound healing.