四川遂宁地区献血者G-6-PD调查及进食蚕豆对蚕豆病儿输血的影响

Study of G-6-PD Deficiency of Blood Donors in Suining Region, Sichuan Province and Influence of Being Transfused with Blood from Donors Eating Broad Beans on Children with Favism

应用改良四唑氮兰法对2483名献血者进行红细胞G-6-PD调查,G-6-PD缺乏率为8.3％,其中显著缺乏率为2.1％。建立献血者G-6-PD调查档案,防止蚕豆病儿输入缺乏G-6-PD的血液,提高了输血安全。观察献血者进食蚕豆后不同时间(2～4小时,12～24小时,2～3天)采血对蚕豆病儿输血的影响,各观察组临床症状与外周血Hb的恢复、G-6-PD活性的改变和对照组比较无明显差别,各组均未发现再溶血病例。提示蚕豆病儿在急性溶血后“不应期”内输入进食了蚕豆的献血者的血液无明显不良影响。

A study of G-6-PD state in red cells of 2483 blood donors was performed using the improved blue tetrazolium method ,indicating that 8.3% of the donors studied were in G-6-PD deficiency and 2. 1% of the donors studied were in severe G-6-PD deficiency. The files of blood donor G-6-PD state were established to prevent the children with favism from being transfused with G-6-PD deficient blood, thereby the safety of blood transfusion could be enhanced. The impact of being transfused with the blood extracted from the donors at different time (2~4 hr. 12-24hr. and 2-3 days )after eating broad beans on the children with favism was observed. There was no obvious difference in the improvement of clinical symptoms,restoration of hemoglobin in peripheral blood and change of G-6-PD activity between the tested and control groups. There were no found the cases of rehemolytic reaction in either group,indicating that being transfused with the blood from donors eating the broad beans had no evident adverse influence on the children with favism during the 'refractory period' following the acute hemolysis.