C反应蛋白与急性冠状动脉综合征的相关性研究

Relationship Between C-reactive Protein and Acute Coronarterial Syndrome

目的:探讨炎症标志物C反应蛋白(CRP)与急性冠状动脉综合征(ACS)的相关性。方法:采用免疫散射光比浊法检测了58例冠心病患者(14例急性心肌梗死,21例不稳定型心绞痛,23例稳定型心绞痛)及30例非冠心病对照组的CRP的水平。结果:血清CRP在急性心肌梗死组(16.14±1.82)mg/L和不稳定型心绞痛组(12.25±3.82)mg/L明显高于稳定型心绞痛组(4.73±3.63)mg/L和非冠心病组(2.53±1.26)mg/L(P均<0.01)。且ACS出现心脏事件CRP浓度显著高于同组无并发症者(P<005)。结论:ACS患者血清CRP显著升高,CRP水平与ACS临床过程的严重性显著相关,可以作为评判ACS预后的指标。

Objective:To explore the association between the inflammatory marker C-reactive protein(CRP)and acute coronarterial syndrome(ACS). Methods:We examined the level of CRP of 58 cases with coronary heart disease(14 cases with acute myocardial infarction, 21 cases with unstable angina and 23 cases stable angina)and 30 cases without coronary heart disease by immunodiffusion and turbidimetry method. Results:The serum CRP in acute myocardial infarction group (16.14±1.82 )mg/l and unstable angina group (12.25±3.82 )mg/l is significantly higher than stable angina group (4.73±3.63 )mg/l and no coronary heart disease (2.53±1.26)mg/l(P<0.01)and ACS with heart accident and its CRP concentration are notably higher than the same group without complications(P<0 05). Conclusion: Serum CRP concentration in Patients with ACS is significantly higher and serum CRP concentration is significantly associated with severity clinical process of ACS, thus it can be as an index of evaluating prognosis of ACS.