急性脑梗死患者血浆内皮素水平变化的临床意义

Clinical study of plasma endothelin changes in patients with acute cerebral infarction

[目的]研究急性脑梗死患者血浆内皮素(ET)水平的变化及其与病情预后的关系。[方法]78例急性缺血性脑梗死患者病程均在4 8h内,按梗死面积及神经功能缺损评分分为轻、中、重3组,分别于入院时、入院后3d、10d测定血浆内皮素水平并进行神经功能缺损评分。以2 5例健康体检者血浆内皮素水平作为正常对照组。[结果]3组患者内皮素水平均升高,其中以中、重组与正常对照组比较有显著性差异(P <0 .0 1) ;神经功能缺损评分越高,ET水平越高,且下降速度慢。[结论]脑梗死患者血浆内皮素水平均升高,与病情轻重及与病情进展相关,因此急性期测定ET水平,对判断病情、预后提供一个新的途径。

Objective To study plasma endothlin (ET) changes in patients with acute cerebral infarction and their correlations with prognosis. [Method] The courses of the 78 patients with acute cerebral infarction are all within 48 hours. Their scorings of infarct sizes and neurotic deficiencies are divided into mild, moderate and severe groups, respectively. Their plasma endothelin levels were determined with 3 d and 10 d, and deficiencies on the function of nerves scored on their admission date and after admission. The plasma endothelin levels of 25 healthy examiners were taken as normal controls. [Results] The endothelin levels of the three groups all increased. Compared with the controls, significant differences were observed in the moderate and severe groups(P<0.01). In scoring deficiencies on the function of nerves, the higher the scores were, the higher the ET levels were. [Conclusion] The decrease of the plasma endothlin (ET) levels in patients with acute cerebral infarction has a correlation with the degrees and progress of the patients' disease conditions. Determining the ET levels of the patients in their acute stage offers a new approach to diagnose and prognose the disease.