经肱动脉主干对复发乳腺癌区域动脉灌注化疗体会

Study on chemotherapy to recurrent breast cancer through brachial artery

[目的]探讨经肱动脉主干对复发乳腺癌区域动脉灌注化疗方法。[方法]经肱动脉主干放置静脉穿刺用硅胶管约2 6～2 8cm ,压迫患侧颈总动脉肱动脉,而后采用5氟尿嘧啶(5 -FU) 0 .5 g、MMC10mg、美蓝1mL用生理盐水稀释至2 0mL ,注入导管内。每次用药间隔三四天,4～6次为1个疗程。定期检查血象,密切注意白细胞下降。[结果]2 0例病人局部症状及体征明显缓解,生活质量及生存率提高,为进一步行二次根治术创造了条件。[结论]本方法化疗优于一般化疗方案,其明显优点在于毒副小,疗效佳。

ObjectiveThe chemotherapy plays an important role in the treatment for the breast cancer but suffering from severe side effect. The intra-artery local chemotherapy is one of the holo-chemotherapy and holds many advantadges such as higher local drug concentration of blood, longer contact period between the drug and tumor, less side effect. [Methods] A tube about 26～28 cm was set into the brachial artery and tchemotherapy drug (20 mL) was injected into the tube every 3～4 days. Four to six injections of the drug were performed in a total therapy period. Checking blood was necessary in case of the reduction of WBC. [Result]In 20 patients, local symptoms was relieved obviously and the rate of survive was raised and their qualities of live were improved. This maked the second radical excision possible. [Conclusion] The chemotherapy through the brachial artery shows a more benefit than the common one.