山莨菪碱减轻静脉用红霉素副作用的临床观察

Clinical observation on anisodamine (654-2) reducing side-effect of erythromycin intravenous injection

[目的]探讨山莨菪碱(6 5 4- 2 )减轻静脉用红霉素副作用的临床可行性。[方法]随机选取需用红霉素治疗的儿科患者12 2例,分成观察组和对照组。观察组(6 1例)患者红霉素注射液混合6 5 4- 2注射液静滴;对照组(6 1例)患者单纯静滴红霉素。比较两组红霉素副作用的发生率及被迫停药率。[结果]观察组静滴红霉素副作用发生率为4 2 6 % ,被迫停药率为8%。对照组副作用发生率为83 6 % ,被迫停药率为36 1%。差异具有显著性意义(P <0 .0 1)。[结论]山莨菪碱能有效减轻静滴红霉素的副作用,且具有安全性,值得儿科临床广泛应用。

ObjectiveTo investigate the efficiency of 654-2 on reducting side effect of erythromycin in intravenous injection. [Mehtods] Of 122 children treated with erythromycin by IV drip were divided into two groups randomly. The observed groups (n=61) were given 654-2 intravenously. The controll groups (n=61) were used erythromycin only. [Results] The incidences of side-effect of two groups were 42.6% and 83.6% respectively. There were significant difference between the observed groups and the controll groups on reducing the side-effect of erythromycin (P<0.01). [Conclusion] 654-2 is safety and efficient to reduce side-reaction of of erythromycin in intravenous injection.