改水对林州市食管癌发病率和死亡率的影响

Influence of Standardized Deep Well Water on Morbidity and Mortality of Esophageal Cancer in Linzhou

目的探讨改水对林州市食管癌发病率和死亡率的影响。方法于1996-1998年调查了林州市10个乡344个村食管癌发病率和死亡率。将调查村按照改水类型分为标准改水村犤深机井(井深≥100m)集中供水,改水≥6a犦、非标准改水村犤深机井(井深<100m)集中供水,改水<6a;或不包括山泉水的非机井水犦、未改水村(只饮用山泉水),并在调查村采集水样以蚕豆根尖细胞微核实验检测其致突变性。结果标准改水人群食管癌发病率(73.07/10万)和死亡率(58.86/10万)显著低于非标准改水人群(123.21/10万,110.57/10万)和未改水人群(150.93/10万,115.59/10万);各乡标准改水村人口百分比与各乡食管癌发病率(r=-0.9273,P<0.01)和死亡率(r=-0.9758,P<0.01)呈负相关;随着改水时间的延长,标准改水村人群食管癌发病率和死亡率呈现下降趋势。标准改水村饮用水所致蚕豆根尖细胞的微核数显著低于未改水村(t=5.2098,P<0.01)和非标准改水村(t=2.6324,P<0.01)。结论改水后林州市食管癌发病率和死亡率呈现下降趋势。

Objective To observe the influence of standardized deep well water on mortality and morbidity of esophageal cancer (EC) in Linzhou. In order to test the hypothesis of 'nitrogenous compound metabolised cycling' in etiology of EC. Methods Based on the investigation data collected in 1999 among which some data were from Linzhou Institute of Prevention and Treatment of EC. Three kinds of water were included, standardized deep well water(SDWW) from the well with the depth exceeding 100 meters ,finished time exceeding 6 years; unstandardized deep well water(UDWW) and mountain spring water(MSW). The mortality and morbidity of EC in the the related population. Results There were 281 458 villagers of 165 villages to drink SDWW, 183 289 villagers of 129 villages to drink UDWW and 45 274 villagers of 50 villages to drink MSW. The morbidity and mortality of EC significantly decreased in residents who drank the SDWW compared with those who drank the UDWW and MSW, P<0.01, the morbidity decreased by 42.10/100 000 and 51.59/100 000 respectively, the mortality decreased by 46.77/100 000, 49.08/100 000 respectively. It was also found that number of people drinking SDWW was negatively related to the morbidity and mortality. Conclusion After water supply changed, the drinking water quality turned much better, the morbidity and mortality of EC in Linzhou have showed a decreasing trend.