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^1H磁共振波谱在脑多发性硬化诊断中的价值 被引量：3

Value of 1H Magnetic Resonance Spectroscopy in Diagnosis of Multiple Sclerosis in Brain
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摘要 目的　结合MRI探讨1H磁共振波谱(1HMRS)在脑多发性硬化(MS)诊断中的临床应用价值。方法　选择32例经临床确诊为MS患者进行MR及1HMRS检查,同时与同期同年龄组MRI显示正常者进行对照研究,通过计算峰下面积,对代谢产物氮乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱复合物(Cho)及乳酸(LAC)的浓度进行定量并观察NAA/(Cr+Cho)、Cho/Cr及LAC/Cr等各参数的变化。结果　病变组病例NAA/(Cr+Cho)、Cho/Cr及LAC/Cr值分别为0. 53、1. 47及0. 23,对照组分别为0. 75、1. 19及3. 35。MS病人NAA/(Cr+Cho)值下降,差异有显著性(t值为4. 76,P<0.05),Cho/Cr、LAC/Cr值升高,差异有显著性(t值分别为2. 36、4. 11,P均<0. 05)。结论　1HMRS和MRI互相补充有利于提高MS的诊断。 Objective To evaluate the clinical value of ~1H magnetic resonance spectroscopy(~1H-MRS) in the diagnosis of multiple sclevrosis(MS) in brain.Methods ~1H-MRS was carried out in 32 patients with MS and 32 age-matched healthy control subjects.By calculating the area below peak,the metabolite N-acetylasparatate(NAA),creatine(Cr) choline compouds(Cho),Cho/Cr and lactate(Lac)/Cr were quantified and their changes were observed.Results NAA/(Cr+Cho),Cho/Cr and Lac/Cr were 0.53,1.47 and 0.23 in MS group,and 0.75,1.19 and 3.35 in control group.NAA/(Cr+Cho) decreased in MS group.The difference between 2 groups was statistically singnificant(t=4.76,P<0.05),Cho/Cr and LAC/Cr increased significantly in MS group(t=2.36,4.11,P<0.05). Conclusions The complementation of ~1H-MRS and MRI is helpful to improve diangnostic accuracy of MS.
作者 武传华 周建峰 杨涛
机构地区 沂水中心医院放射科
出处 《现代诊断与治疗》 CAS 2005年第3期136-139,共4页 Modern Diagnosis and Treatment
关键词 ^1H磁共振波谱 脑多发性硬化 诊断 氮-乙酰天门冬氨酸 临床应用价值 HMRS 胆碱复合物 MRI NAA LAC Cho 方法选择 对照研究 代谢产物 显著性 Cr MS 正常者 年龄组 r值 t值 Multiple sclerosis ~1H magnetic resonance spectroscopy Metabolism
分类号 R739.41 [医药卫生—肿瘤] R744.51 [医药卫生—神经病学与精神病学]
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参考文献10

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二级参考文献1

共引文献17

同被引文献17

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现代诊断与治疗
2005年 第3期

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