电控大鼠脊髓损伤打击器的研制

Development of an electrocircuit controlled impact device for injuring spinal cord in adult rats

目的研制一种新型的致大鼠不同程度脊髓损伤的打击装置,为制作大鼠脊髓损伤标准化模型提供新的科学手段。方法在打击锤两侧安装两个激光发射头,通过发射的两束激光的交点来确定打击锤的打击点。采用重物下落致伤技术及根据电磁吸附原理,设计高度调节电路,控制微型电机转动,通过涡轮涡杆精确调节打击锤的高度;设计时间控制电路,使打击时间恒定在100ms内完成。结果该打击仪能够实现定时、瞬时,定点、定高打击,可以制作不同程度的脊髓损伤模型。结论激光定位的电控大鼠脊髓损伤打击装置,具有操作简单、灵活方便、精确度高、可重复性好的特点。

Objective To develop a new impact device that can cause different levels of spinal cord injury in adult rats so as to provide a scientific means for standard spinal cord injury model in adult rats. Methods First, two laser heads were installed beside the impacting hammer in order to define the dropping point of imparting hammer through the focus of the two tracts of lasers. A height controlled electrocircuit was designed to control the rotation of the minitype dynamo that regulated the height of impacting hammer precisely via the worm gear. Meanwhile, a time controlled electrocircuit was made so as to secure that the process of injury could be finished within 10 millionseconds constantly according to the technique of weight dropping and the principle of electromagnetic electromagnetism respectively. Results The present impact device could produce different levels of spinal cord injury in adult rats within special times, heights and dropping points. Conclusion We have successfully produced an electro-circuit controlled impact device with laser defining position that is simple and easy to use for making controllable and precise injury models.