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新鲜羊膜移植治疗芥子气角膜损伤的实验研究 被引量:2

Fresh amniotic membrane transplan-tation for healing of rabbit corneal wound caused by mustard gas
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摘要 目的:研究新鲜羊膜移植治疗芥子气角膜损伤的治疗作用。方法:新西兰白兔9只,用浓度为500μL/L的液态芥子气致伤双眼角膜5min,右眼为治疗组,用新鲜羊膜移植治疗,左眼为对照组,不治疗。结果:新鲜羊膜移植术后治疗眼的急性刺激症状明显较对照眼减轻,上皮愈合快,但病理检查显示治疗组的眼前节炎性反应并不比对照组有明显减轻。结论:新鲜羊膜移植可作为治疗中度芥子气角膜损伤的方法。 · AIM: To evaluate the effect of fresh amniotic membrane transplantation in healing rabbit corneal wound caused by mustard gas.· METHODS: The corneas of 9 New Zealand white rabbits were injured by liquid mustard with the concentration of 500μL/L. The right eye of each rabbit was treated with fresh amniotic membrane transplantation, and the left one without treatment as the control.· RESULTS: The epithelial healing rate of the treated eyes was higher than that of the control group. The treated eyes had much fewer irritating symptoms. However, histopathological study showed that there was no significant difference in inflammation reactions of the anterior segment between the two groups.· CONCLUSION: Fresh amniotic membrane transplantation can be a therapeutic method for rabbit corneal epithelial wound caused by liquid mustard.·
出处 《国际眼科杂志》 CAS 2005年第2期256-258,共3页 International Eye Science
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  • 1[1]Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology, 1997,104: 2068 ~ 2076.
  • 2[2]Hawkins SL,Hartley CE,Mylotte MJ,et al. Brit J Obste Gynaec,1982,89:226
  • 3[3]Gray BM,Spring-field JD,Dillon HC,et al. Am J Obstet Gynecol,1987,156:666
  • 4[4]Bae-Li Hsi,Danielle F,Chang-Jing G.Yeh,et al. Invest Ophthal,1986,27:620
  • 5Szekanecz Z, Shah MR, Pearce WH. Intercellular adhesion molecule-1 (ICAM-1) expression and soluble ICAM-1 (sICAM-1) production by cytokine-activated human amniortic endothelial cells: a possible role for ICAM-1 and sICAM-1 in atherosclerotic aortic aneury
  • 6Abrham S, Mark R, Dagoberto M, Dagoberto M, Zhong H J, Stephen CP,Scheffer CG, Tseng SCG. Suppression of 1 α and interleukin 13 in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol, 2001;85:444-449
  • 7KimJC, TsengSCG. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbits cornea. Cornea,1995; 14(5):473-484
  • 8Harminder SD, Augusto AB. Amniotic membrane transplantation. Br J Ophthalmol, 1999;83:748-752
  • 9Kruse FE, Rohrschneider K, Vyoloker AE. Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology,1999; 106:1504
  • 10Shimazaki J, Yang HK, Tsubota K. Amniotic membrane transplantation for ocular reconstruction in patients with chemical and thermal burns. Ophthalmology,1997;104(12):2068-2075

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  • 1蔡季平,赵杰,胡维国,朱明学.纤维连接蛋白对芥子气兔眼角膜损伤的治疗[J].毒理学杂志,2001,17(z1):62-62. 被引量:1
  • 2蔡芸,马骞,张黎明,赵杰,朱明学,胡卫江,汤球,江鹏亮.芥子气中毒对家犬生殖系统的影响[J].中国公共卫生,2004,20(6):664-665. 被引量:4
  • 3王汉斌,牛文凯,赵德禄.芥子气中毒的诊治[J].中华内科杂志,2005,40(1):62-64. 被引量:8
  • 4Zhang Z,Riviere JE,Monteiro-Riviere NA.Evaluation of protective effects of sodium thiosulfate,cysteine,niacinamide and indomethacin on sulfur mistard-treated isolated perfused porcine skin.Chem Biol Interact,1995,96(3):249
  • 5Meier HL,Millard CB.Alterations in human lymphocyte DNA caused by sulfur mustard can be mitigated by selective inhibitors of poly(ADP-ribose) polymerase.Biochim Biophys Acta,1998,1404(3):367
  • 6Moser J,Meier HL.Comparison of cell size in sulfur mustardinduced death of keratinocytes and lymphocytes.J Appl Toxicol,2000,20(Suppl 1):S23
  • 7Meire HL,Johnson JB.The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agents 2.2'-dichlorodiethyl sulfide(sulfur mustard,HD).Toxicol Appl Pharmacol,1992,113(2):234
  • 8Yourick JJ,Dawson JS,Mitcheltree LW.Sulfur mustard-induced microvesication in hairless guinea pigs:effect of short-term niacinamide administration.Toxicol Appl Pharmacol,1992,117(1):104
  • 9Bhat KR,Benton BJ,Rosenthal DS,et al.Role of ploy(ADP-ribose) polymrtase(PARP) in DNA repair in sulfur mustard-exposed normal human epidermal keratinocytes(NHEK).J Appl Toxicol,2000,20:13
  • 10Ray R,Benton B,Janderson DR,et al.Intervention of sulfurmustard toxicity by downregulation of cell proliferation and metabolic rates.J Appl Toxicol,2000,20:S87

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