多发性硬化患者血清及脑脊液中RANTES水平的研究

A Study on the Level of RANTES in Serum and Cerebrospinal of Patients with Acute Multiple Sclerosis

目的 探讨趋化因子RANTES在多发性硬化发病中的作用。方法 用ELISA法对20例急性期多发性硬化(MS) 患者和20例紧张性头痛及神经衰弱患者(对照组) 的血清及脑脊液中的RANTES浓度进行测定, 并与脑脊液(CSF) -IgG指数进行相关性分析。结果 急性期MS患者血清及脑脊液中RANTES浓度与对照组间差别有显著性意义(P<0. 05); 脑脊液中趋化因子RANTES浓度与脑脊液(CSF) -IgG指数间无相关性。结论 MS患者急性期血清和脑脊液中RANTES浓度增高, 说明趋化因子RNATES可能参与MS的发病过程。

Objective To investigate the effects of c hemokine RANTES in the pathogenesis of the Patients with Acute Multiple Sclerosi s(MS).Methods The level of serum and cerebrospinal fluid(CS F) RANTES in 20 patients with clinical definite MS in an acute phase and in 20 p atients with tension headache and neurasthenia were measured.Results RANTES concentration in serum and CSF from acute MS patients was incre ased compared to the control′s.Conclusion The level of ser um and CSF RANTES in MS patients increases at acute phase,being involved in infl ammation,Chemokine may be implicated in the pathogenesis of MS.