肝病患者ADA、ALT、GGT的检测及其意义的探讨

Significances of Detection of Serum ADA, ALT and GGT for Patients with Hepatic Patients.

目的 :了解肝病患者血清ADA以及ALT、GGT对肝病的诊断、鉴别诊断和预后的价值。方法 :对 113例肝病患者、2 7例正常对照者血清进行ADA、ALT、GGT检测。结果 :肝硬化组的ADA为 43 . 15± 11 .7U/L ,阳性率为 93 . 6%;慢性活动性肝炎组ADA为 3 8 . 78± 12 . 1U/L ,阳性率为 88 . 9%,与正常对照组相比升高明显 ,P <0. 0 1;急性肝炎组ADA为3 0 . 2 4± 10 . 3U/L ,阳性率为 83 2 %,与正常对照组相比也有明显升高 ,P <0 . 0 5 ;而ALT在急性肝炎中为 3 78 . 92± 114 6U/L ,阳性率为 10 0 %,明显高于正常对照组 ,P <0 0 1。GGT在急性肝炎和肝硬化时升高 ,尤其在肝硬化时升高明显 ,为95 . 3± 2 2 . 1U/L ,阳性率为 68 . 6%。结论 :ADA在鉴别慢性活动性肝炎和慢性迁延性肝炎以及肝硬化方面优于ALT和GGT ,ALT在反映急性肝炎方面仍具有一定的临床意义 ,而GGT有助于判断肝硬化向肝癌方面的转变。

Objectives:To study the significances of detecting ADA, ALT and GGT for patients with hepatic diseases in diagnosis, differential diagnosis and prognosis of hepatic diseases. Methods: We detected serum ADA, ALT and GGT of 113 patients with hepatic diseases. There were 27 cases in the control group. Results: ADA for the cirrhosis group was 43.15(11.7 UL and the positive rate was 93.6%. For chronic active hepatitis group, they were 38.78(12.1 UL and 88.9% respectively. For acute hepatitis group, they were 30.24(10.3 UL and 83.2% respectively. They were all significantly higher than those of the control group. ALT was increasing for the acute hepatitis group, which was 378.92(114.6UL, and the positive rate was 100%. GGT was also increasing for the acute hepatitis and cirrhosis groups. Conclusions:ADA is a better indicator in differentiating chronic active hepatitis, chronic persistent hepatitis and cirrhosis than ALT and GGT. And ALT can be used in diagnosing acute hepatitis. GGT is a good indicator to diagnose cirrhosis changing into hepatocarcinoma.