溴化铜催化合成乙酸叔丁酯

Catalytic Synthesis of tert-Butyl Acetate With Copper(Ⅱ) Bromide

以溴化铜为催化剂,通过酰化法制备了乙酸叔丁酯,并用红外光谱进行了表征。以叔丁醇和乙酸酐为反应原料,探讨了溴化铜对合成乙酸叔丁酯的催化性能,详细考察了反应温度、反应时间、催化剂的摩尔分数及反应酐醇摩尔比等影响酰化反应的各种因素,得出了乙酸酐和叔丁醇反应的较优条件。实验结果表明,溴化铜对实现乙酸酐与叔丁醇的酰化反应具有良好的催化性能,有一定的可行性和工业实用价值。溴化铜催化合成乙酸叔丁酯的优化条件为:回流温度下,酐醇摩尔比为1.4∶1,溴化铜在醇中的摩尔分数为0.5%,反应2h,乙酸叔丁酯收率达83.46%。

By using copper(Ⅱ) bromide as catalyst, tert-butyl acetate was synthesized via acylation and the product was determined by infrared spectrometry. By using tert-butyl alcohol and acetic anhydride as raw material, the catalytic behavior of copper(Ⅱ) bromide was discussed in synthesizing tert-butyl acetate. Various factors such as reaction temperature, reaction time, mole fraction of catalyst and molar ratio of anhydride to alcohol, et al, which influence the acylation reaction, were investigated in detail. The optimum reaction conditions were given. The results indicate that copper(Ⅱ) bromide exhibit excellent catalytic activity for the acylation reaction of tert-butyl alcohol and acetic anhydride. It is fairly feasible and has practical value in industry. The optimum reaction conditions are as following: reflux temperature, the molar ratio of anhydride to alcohol is 1.4∶1, reaction time is 2 hours, the mole fraction of copper(Ⅱ) bromide in alcohol is 0.5%, the yield of tert-butyl acetate is 83.46%.