489例不良孕产史患者细胞遗传学分析

Analysis of chromosomal karyotypes in 489 patients with badness pregnancy history.

目的 探讨染色体异常对生育的影响。方法 对4 89例有自然流产、胎停育或生育畸形儿史的患者进行外周血淋巴细胞培养,G显带染色体核型分析。结果 4 89例患者中染色体核型异常2 4例,异常率达4 .9% ,其中有自然流产、胎停育史的患者核型异常占2 0例,有生育畸形儿史的患者核型异常占4例。染色体变异共2 1例,占4 .3%。结论 染色体异常是导致不良生育的重要影响因素,应重视遗传学检查,进行优生优育指导。

Objective:To study the effect of chromsosmal abnormalities on pregnacy. Methods: Chromosomal karyotypes were examined in 489 patients with spontaneous abortion or embryo growth ceasing or bearing malformation child history by periphery blood lymphocyte culture and G banding. Results: Chromosomal abnormalities were checked out in 24 patients (4.9%), including 20 patients with spontaneous abortion or embryo growth ceasing and 4 patients with bearing malformation child history. Conclusion: Chromosomal abnormalities play an important role in badness pregnancy.