哮喘急性发作患者肾素－血管紧张素－醛固酮含量与辨证分型关系的研究

Rein-angiotensin-aldosterone in acute asthmatic at-tack:relationship between their contents and the typesof asthma classiffed on the basis of a theory of Tradi-tional Chinese Medicine(″differentiation of symptomsand signs″)

对４７例哮喘急性发作患者，就肾素－血管紧张素－醛固酮含量与中医辨证分型关系进行研究，发现哮喘组肾素活性（ＰＲＡ）含量高于对照组（Ｐ＜０．０１）；血管紧张紊Ⅱ（ＡＴ－Ⅱ）以寒哮组增加最为明显（Ｐ＜０．０１）；醛固酮（ＡＬＤ）热哮组低于对照组（Ｐ＜０．０５）。哮喘组ＰＲＡ与ＰａｃＯ＿２呈负相关，热哮组ＡＬＤ与ＰａＣＯ＿２呈正相关。并发现ＰＲＡ，ＡＴ－Ⅱ随病情加重而升高。死亡者ＰＲＡ水平高于缓解患者（Ｐ＜０．０１）。提示：ＰＲＡ可作为哮喘患者预后判断及疗效考核指标。

We studied the contents of renin-angiotensinaldosterone in 47 patients with acute asthmatic at-tacks and analyzed thcir relationship with the typesof asthma classified on the basis of the theory″differentiation of symptoms and slgn″(a theory oftrad itional Chinese medicine)The level of renin washigher in the group of asthma than in the controlgroup(p<0.01)Angiotensin Ⅱ was markedly in-creased in the group of ″,cold″asthma(P<0.01).Aldosterone was lower in the group of ″hot″asthmathan in the control group(P<0.05)There was a neg-ative correlation between renin and PaO_2in the groupof asthma.Aldosterone was positively correlated withPaO_2in the group of ″hot″asthma. Renin andangiotensin Ⅱ were increased with the deteriorationof the disease.Renin level was higher in the patientswho died than the patients who became remitted(P<0.01),It is suggested that renin maybe used asanind icator to assess the prognosis and the therapeuticeffectivene8s in asth matic patients.