内毒素血症中神经肽Y含量的变化及其对流动力学的影响

Changes of neuropeptide Y and its effect onhemodynamics in rats with endotoxemia

用６－羟多巴胺（６－ＯＨＤＡ）抑制交感神经释放神经肽Ｙ（ＮＰＹ）的作用，观察内毒素血症时ＮＰＹ对大白鼠心率（ＨＲ）、平均动脉压（ＭＡＰ）、心输出量（ＣＯ）、中心静脉压（ＣＶＰ）和总末梢血管阻力（ＴＰＲ）变化的影响。结果表明：抑制ＮＰＹ释放后再给予内毒素时，血浆中ＮＰＹ含量上升２４Ａ％，同时动物的ＭＡＰ和ＴＰＲ与内毒素血症对照组相比，分别降低约９．５％和１３．７％（Ｐ均＜０．０５）。注射外源性ＮＰＹ后，ＭＡＰ、ＣＯ和ＣＶＰ与内毒素血症对照组相比，则分别升高３４．６％、１５．６％和１５６．５％（ｐ均＜０．０１），而ＴＰＲ则比单纯抑制ＮＰＹ组升高３２．５％（Ｐ＜０．；０１）。另外给予致死剂量内毒素后，动物的存活时间为５０．７０±９．１７ｍｉｎ；同时给予６－ＯＨＤＡ时，动物的存活时间则延长至１７６．６０±４８．３０ｍｉｎ（Ｐ＜０．０１）。提示内毒素血症早期，血浆中ＮＰＹ含量的升高参与了血流动力学的调节。

We studied changes of plasma neuropeptide Y(NPY) and the relationship between plasma NpYand changes of mean arterial pressure (MAP),heartrate(HR) ,cardiac output(CO) ,central venous pres-sure(CVP)and total peripheral resistance (TPR) inrats with endotoxemia.It was found that released volume of NPY by endotoxin was only increased by24.4%when NPY was inhibited previously by6-hydroxydopamine(6-OHDA),and meanwhile,MAP and TPR decreased Significantly by about9.5% and13.7%,respectively(p<0.05) in compari-son with the control endotoxemia group-As soon asexogenous NPY was given,the level of MAP, CO,CVP increased significantly(about 34.6%,15.6%,156.5%,respectively as compared with the controlendotoxemia group),however,TPR was increased byabout 32.5%(p<0.01)compared with the NPY inhi-bition group,In addition,the mean survival time forrats given a lethal dose of endotoxin was50.7±9.2minutes,but was increased to 176.6±48.3 minuteswhile 6-OHDA was simultaneously administered(p<0.01).It is considered that the increased plasmaNPY,as an important compensatory mechanism,is involved in the regulation of hemodynamics duringthe early stage of endotoxemia。