摘要
应用放射免疫测定法测定了46例急性腋血管病患者(脑出血22例,脑血栓24例)和40例健康正常人血浆胃动素浓度。脑出皿和脑血栓血浆胃动素含量分别为447.67±88.18ng/L和412.04±101.74ng/L,均分别较健康正常人的水平(309.79±66.46ng/L)明显升高(P<0.01);而疾病组间比较无显著差异(P>0.05)。急性脑血管病伴意识障碍及消化道症状时,血浆胃动素水平均较意识正常及无消化道症状者显著升高(P<0.01);并与脑血肿量呈线性正相关(r=0.70,P<0.01);不同病变部位的血浆胃动素变化无显著性差异(P>0.05)。疾病恢复期血浆胃动素水平较急性期显著下降(P<0.01),与健康正常人比较差异不显著(P>0.05)。作者对急性脑血管病血浆胃动素水平升高的可能机理作了初步探讨。
Plasma motilin level was determined byradioirnmunoassay in 46
patients with acutecerebrovascular disease(22 hemorrhagic and24thrombotic strokes) and40
normal subjects.The re-sults showed that the average plasma motilin levels inboth
hemorrhagic(447.67±101.74ng/L) andthrombotic patients(412.04±101.74ng/L) werehigher than
that of the normal subjects(309.79±66.46 ng/L,P<0.01).No significant difference wasrevealed
between plasma motilin levels of the twogroups(hemorrhagic patients and thrombotic pa-tients).
The plasma motilin levels were higher instuporous or comatose patients and patients
withgastrointestinal symptoms than those in consciouspatients and patients without
gastrointestinal symp-toms, and had a linear positive correlation with thesize of intracrebral
hematomas(r=0.70,P< 0.01) The plasma motilin level decreased when the pa-tients condition
was improving.The mechanism ofthe elevation of plasrna motilin level in acuteberebrovascular
disease was discussed。
出处
《中国危重病急救医学》
CAS
CSCD
1994年第3期152-153,共2页
Chinese Critical Care Medicine
关键词
胃动素
脑血管疾病
病理
cerebrovascular disease
motilin:radioimmunoassay