急性脑血管病血浆胃动素水平的研究

Preliminary study on plaslna motilhlewels in acutecerebrovascular diseases

应用放射免疫测定法测定了４６例急性腋血管病患者（脑出血２２例，脑血栓２４例）和４０例健康正常人血浆胃动素浓度。脑出皿和脑血栓血浆胃动素含量分别为４４７．６７±８８．１８ｎｇ／Ｌ和４１２．０４±１０１．７４ｎｇ／Ｌ，均分别较健康正常人的水平（３０９．７９±６６．４６ｎｇ／Ｌ）明显升高（Ｐ＜０．０１）；而疾病组间比较无显著差异（Ｐ＞０．０５）。急性脑血管病伴意识障碍及消化道症状时，血浆胃动素水平均较意识正常及无消化道症状者显著升高（Ｐ＜０．０１）；并与脑血肿量呈线性正相关（ｒ＝０．７０，Ｐ＜０．０１）；不同病变部位的血浆胃动素变化无显著性差异（Ｐ＞０．０５）。疾病恢复期血浆胃动素水平较急性期显著下降（Ｐ＜０．０１），与健康正常人比较差异不显著（Ｐ＞０．０５）。作者对急性脑血管病血浆胃动素水平升高的可能机理作了初步探讨。

Plasma motilin level was determined byradioirnmunoassay in 46 patients with acutecerebrovascular disease(22 hemorrhagic and24thrombotic strokes) and40 normal subjects.The re-sults showed that the average plasma motilin levels inboth hemorrhagic(447.67±101.74ng/L) andthrombotic patients(412.04±101.74ng/L) werehigher than that of the normal subjects(309.79±66.46 ng/L,P<0.01).No significant difference wasrevealed between plasma motilin levels of the twogroups(hemorrhagic patients and thrombotic pa-tients). The plasma motilin levels were higher instuporous or comatose patients and patients withgastrointestinal symptoms than those in consciouspatients and patients without gastrointestinal symp-toms, and had a linear positive correlation with thesize of intracrebral hematomas(r=0.70,P< 0.01) The plasma motilin level decreased when the pa-tients condition was improving.The mechanism ofthe elevation of plasrna motilin level in acuteberebrovascular disease was discussed。