小儿肾功能不全尿Tamm－Horsfall蛋白测定的临床意义

Clinical significance of determination of Tam- Horsfall protein in urine of children with rena linsufficency

对８０例小儿肾脏疾病患者的尿Ｔａｍｍ＋Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）２４ｈ含量进行检测，并与正常组比较。结果：肾功能不全组ＴＨＰ低于正常，单纯肾病极期高于正常，急性肾炎早期与正常无差异。肾功能不全时，随血ＢＵＮ升高，尿ＴＨＰ相应下降，呈负相关；肾小球疾病极期伴有一过性氮质血症与肾功能不全时出现氮质血症患儿的尿ＴＨＰ含量有明显差异，临床上具有鉴别诊断意义。

24-hour urine Tamm-Horsfall protein (THP)determined in 80 children wi,hrenal disease wascompared with that in normal controls.The authorsbund that the TH P in renal insufficiency patientswas below normal level,that in patients at the climaxof simple nephrosis was higher than normal ,and thatin patients in the early stage of acute nephritis wassimilar to normal.In renal dysfunction,BU N was in-creased , and urine TH P was correspondingly de-creased , which showed a negative correlation be-tween the two opposite changes,Significant differ-ence in the urine THP was found between translentazotemia at the climax of glomerular diseads andazotemia due to renal dysfunetion,which appearedto be of diagnostic significance.