摘要
本研究旨在证明大黄是否对出血性休克大鼠肠粘膜屏障具有保护作用。实验用雄性ＳＤ大鼠，右侧颈动脉放血，血压５．３２ｋＰａ（４０ｍｍＨｇ）维持１ｈ，失血回输，观察２４ｈ。大黄（１５０ｍｇ／ｋｇ）于复苏后即刻、６ｈ、１２ｈ分次经胃管注入。实验结果：①内脏含菌量：大黄治疗组大鼠各器官含菌量明显低于休克组和安慰剂治疗组（Ｐ＜０．０１）。②血浆内毒素水平：复苏后２４ｈ，大黄治疗组大鼠血浆内毒素水平明显低于休克组和安慰剂治疗组（Ｐ＜０．０１）。③病理形态学改变：大黄治疗组小肠病理改变程度明显轻于休克组和安慰剂治疗组。提示：大黄对出血性休克大鼠肠粘膜屏障有明显保护作用。
Hemorrhagic shock-induced injury to gut barri-et, is pathologically common,The goal
of this experi-ment was to determine wherher traditional Chinesemedicine rhubarb would have a
good curative effecton gut barrier damage induced by hemorrhagic shock,Bloodletting via right
cervical artery was per-formed in male Sprague-Dawley rats to inducehemorrhagic shock.The
mean arterial pressure wasreduccd to 5.32 kPa(40 mmHg) and maintained for60 minutes.The
animals were resuscittated by reinfus-ing all of the shed blood at the end of
shock,Rliubarb(50mg/kg) via oral-gastric tube was administered10 the animals each time at the
end of resucitation and 6、12hours after resuscitation The results showed that the rats in
rhubarb group had lower in-Cidenceof bacterial transloction to mesenteric lymph nodes than the
rats in shock group(P<0.05);the rats in rhubarb group had smaller numbers of viable bacteria
contained in the liver ,spleen and mesenteric lymph nodes than the rats inshock group and
placebo group(P<0.01);the ratsin rhubarb group had lo wer level of endotoxin in se-rum than the
rats in shock group and placebo group(P<0.01);the histologic damage seen in the smallintestine
of the rats in rhubarb group was milder than that in shock group and placebo
group,Hence,hemorrhagic shock might cause disruptlon of the gutbarricr and rhubarb could
protect the gut barrierfrom being damaged by hemorrhagic shock.
出处
《中国危重病急救医学》
CAS
CSCD
1994年第6期329-331,共3页
Chinese Critical Care Medicine
