Toll样受体识别机制及其生物学意义

Recognition Mechanism of Toll-like Receptors and its Biological Signification

Toll样受体介导的信号转导通路在对抗外来病原体的天然免疫应答中起重要作用。Toll样受体是一个天然模板识别受体家族,能识别固有性模板(微生物和哺乳动物所共有的病原相联的分子模板PAMPs)。Toll样受体通过巨噬细胞和其他免疫细胞来识别,其中TLR4识别内毒素、TLR2识别肽聚糖、TLR9识别细菌DNA、TLR5识别鞭毛蛋白、TLR3识别双链RNA等。本文探讨了多种Toll受体家族成员在动物体内识别机理及功能,概述了其应用研究进展。

The signaling pathway induced by Toll-like receptors(TLRs) play an important role in the innate immune response. TLRs are a family of innate immune pattern recognition receptors(PRRs) that recognize conservered molecular patterns(pathogen-associated molecular patterns, PAMPs), which are shared by large groups of microorganisms. Mammalian TLRs function as PRRs, through which macrophages and other defensive cells sense endotoxin(TLR4), peptidoglycan(TLR2),bacterial DNA(TLR9), flagellin(TLR5) and double-stranded RNA(TLR3), et al. The mechanism and function of TLRs in animals are discussed. The future work on TLRs are also included.