细胞ABCA1／apoA—Ⅰ转脂途径的研究进展
摘要
三磷酸腺苷结合盒转运子(ABCA1)促进胆固醇流向载脂蛋白A1(ap0A—Ⅰ)是调控细胞胆固醇代谢平衡的一个重要环节，特别是在肝细胞和动脉粥样硬化斑块内的巨噬泡沫细胞，apoA—Ⅰ／ABCA1转脂途径决定了胆固醇逆向转运的效率。apoA—Ⅰ与ABCA1触发的信号通路能够稳定膜上ABCA1，为抗动脉粥样硬化(AS)药物设计提供潜在靶点。
出处
《美国中华临床医学杂志》
2005年第1期72-73,76,共3页
American Journal of Chinese Clinical Medicine
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