摘要
新药研究中剂量与效应关系研究贯穿于各期临床试验中,可变剂量设计具有一定优势。本文列出了设计类型、特点和注意事项,另外用一个降血脂实例进行说明。
Titration to optimal effect is the central principle in the treatment of diseases with medications, and an important approach for the study of dose-response relationship. This paper lists different types, characteristics and important points in the design. An example of rosuvastain calcium is given by the design in clinical trail.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第4期479-480,共2页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
临床试验
量效关系
试验设计
血脂
可变剂量
剂量滴定
瑞舒伐他汀
clinical trial
dose-response relationship
changeable dose design
blood lipid
trail design
rosuvastatin
