摘要
目的动态观察脑梗塞患者起病后外周血中LTB4的浓度变化,了解LTB4在脑梗塞发病中的作用。方法采用酶联免疫吸附法(ELISA)测定脑梗塞患者发病3、7、14～21d时外周血LTB4的含量,以眩晕症患者作为对照。结果脑梗塞患者外周血LTB4含量在发病3、7、14～21d均较对照组高,差异有显著性。结论LTB4参与了脑梗塞的发病过程。测定外周血LTB4含量可反映局部脑组织中LTB4的活性反应。
Objective To study on the time-related changes of plasma LTB4 in patients with cerebral infarction, and to study the role of LTB4 in cerebral infarction. Method The concentrations of LTB4 in peripheral circulation plasma of patients with cerebral infarction were measured at 3, 7 and 14～21 days afte r onset by ELISA. The same method was applied to the control group. Result Pla sma LTB4 at 3 days,7 days and 14～21 days after onset are all elevated compared to that of the control group. Conclusion LTB4 may play a role in the cerebral i nfarction. Peripheral circulation LTB4 concentration indicates the inflammatory response in the local infarction focus.
出处
《热带医学杂志》
CAS
2005年第3期297-298,375,共3页
Journal of Tropical Medicine
基金
广东省自然科学基金(No.21894)
关键词
LTB4
炎症介质
脑梗塞
LTB4
inflammatory mediator
cerebral infarction
