多孔硅酸钙生物陶瓷的制备及体外活性和降解性研究

Fabrication and the Characterisation of the Bioactivity and Degradability of Macroporous Calcium Silicate Bioceramics in vitro

以聚乙二醇为造孔剂,制备了多孔硅酸钙生物陶瓷.应用本文提供的方法,可制得孔连通性好、气孔率53.7%-73.6%、抗压强度4.9-48.5MPa、大孔孔径200-500μm的多孔陶瓷.研究表明,多孔硅酸钙生物陶瓷的力学强度随造孔剂含量的增加而明显降低,而气孔率则相反.应用模拟体液浸泡实验研究了多孔陶瓷的体外生物活性和降解性.研究表明,样品在模拟体液中浸泡1天表面就全部被碳酸代羟基磷灰石层覆盖住.气孔率为63.1%的样品7天的降解率达7.14%,具有良好的降解性.研究结果显示多孔硅酸钙生物陶瓷有望作为硬组织修复支架材料用.

Macroporous calcium silicate bioceramics with interconnected pore structures were prepared by adding PEG as pore-forming agent. The porosity and the compressive strength were controlled between 53.7% and 73.6% and 4.9MPa and 48.5MPa, respectively, by the regulation of PEG amount. The samples with porosity of 63.1% were soaked in simulated body fluid (SBF) to investigate their bioactivity and degradability. After soaking in SBF for I day, the samples were completely covered by hydroxycarbonate apatite layers. The degradability of the samples reached 7.14% after soaking in SBF for 7 days. The results suggested excellent in vitro bioactivity and degradability of the macroporous calcium silicate ceramics. Therefore, these macroporous calcium silicate ceramics may be potential candidates as bioactive and degradable scaffolds for hard tissue repair and tissue engineering applications.