维生素K_3对家兔输尿管平滑肌动作电位和尿路动力学的影响

Effects of Vitamin K_3 on action potential of Ureteral Smooth muscle and Urodynamics in rabbits

目的探讨维生素K3对输尿管平滑肌动作电位和尿路动力学的影响。方法采用在体电活动记录观察实验前后输尿管平滑肌动作电位频率及尿路动力学变化。结果维生素K3能显著降低输尿管平滑肌动作电位的频率和输尿管内压力,并使尿流量增加。结论维生素K3对兔输尿管平滑肌产生一定负性影响,但对尿流量却有增加作用,其尿量增加的作用有助于输尿管结石的排出。

Objective To study the effects of Vitamin K_3 on ureteral smooth muscle action potential and urodynamics in rabbits. Methods By using in vivo electrical activity recording,the effects of Vitamin K_3 on the frequency of ureteral smooth muscle action potential and urodynamics in rabbits were studied before and after administration of Vitamin K_3 . Results The Vitamin K_3 can greatly decrease frequency of ureteral smooth muscle action potential,and can greatly decrease ureteral pressure and increase urine flow. Conclusions The results suggested that Vitamin K_3 have negative effeets on rabbit smooth muscle of the ureter but increas urine flow. The increasing effect in urine flow helps expel ureteral stone.