p27^(kip1)和Ki-67在子宫内膜样腺癌中的表达

Expressions of p27^(kip1) and Ki-67 in Endometrioid Carcinoma

目的 探讨子宫内膜样腺癌中p2 7kip1和Ki -6 7蛋白的表达情况。方法 采用免疫组化法检测30例子宫内膜样腺癌、10例子宫内膜不典型增生及2 0例正常子宫内膜中p2 7kip1和Ki -6 7蛋白的表达。结果 p2 7kip1蛋白在正常子宫内膜、不典型增生及子宫内膜样腺癌中的表达逐渐降低,存在显著差异(P <0 .0 0 1) ,并与组织的恶性程度呈负相关(P <0 .0 0 1)。在正常子宫内膜与子宫内膜不典型增生及子宫内膜样腺癌中的Ki 6 7表达存在差异(P <0 .0 0 1) ,Ki 6 7标记指数与组织的恶性程度呈正相关(P <0 .0 0 1)。各种病变子宫内膜组织中p2 7kip1的表达与Ki6 7标记指数呈负相关(P <0 .0 0 1)。结论 p2 7kip1蛋白表达的下降及Ki- 6 7的表达升高可能与子宫内膜腺癌的发生有关。

Purpose To study the expressions of p27ki p1 and Ki-67 in endometrioid carcinoma. Methods Expressions of p27 kip1 and Ki-67 was det ected in 30 endometrioid carcinoma,10 endometrial atypical hyperplasia and 2 0 normal endometrium by immunohistochemical technique. Results Expressions of p27 kip1 in normal endometr ium,endometrial atypical hyperplasia and endometrioid carcinoma have significant ly difference(P<0.001),and that was negatively related to the malignant degr ee(P<0.001).While Ki-67 Label Indexs of normal endometrium?endometrial aty pical hyperplasia and endometrioid carcinoma were also significantly different( P<0.001),but which was positively related to the malignant degree (P<0.0 01).Further study showed there was negative relationship between the expressions of p27kip1 and Ki-67 in endometrium diseases. Conclusions Low expression of p27 kip1 and high ex pression of Ki-67 may play a role in the endometrial caricinogenesis.