摘要
首次以天然D-樟脑的衍生物为原料,合成了两个新型龙脑基氨基醇配体,研究了它们与硼烷原位制备成手性噁唑硼烷后,在不对称催化氢化还原前手性芳酮中的性能,得到的手性仲醇的对映体过量(ee)值最高可达96%,还考察了反应温度、时间、溶剂等因素对苯乙酮的不对称氢化还原的化学产率和光学收率的影响.
Two camphyl aminoalcohols were synthesized from the ramification of natural D-camphor. The formed chiral oxazaborolidines in situ have been used in the enantioselective borane reduction of prochiral ketones affording the alcohol products with enantiomeric excesses (ee) up to 96%. The effects of reaction temperature, time and solvent on the yield and the enantioselectivity of asymmetric reduction of acetophenone were investigated.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2005年第6期669-672,共4页
Chinese Journal of Organic Chemistry
基金
教育部高等骨干教师资助基金(No.200065)
淮海工学院自然科学研究基金(No.Z2003008)资助项目.
