早老症合并高血压和冠心病（附一例尸检报告）

A CASE OF PROGERIA COMPLICATED WITH HYPERTENSION AND CORONARY HEART DISEASE

早老症在文献中极为少见。本文报道１例早老症及其尸检资料。患儿男性，１２岁。自出生４～５个月起，即出现头发脱落、毛发稀少、皮肤变薄以及色素沉着等特征。以后随年龄增长，逐渐呈现老年人面貌。５岁时，发现有高血压和冠心病，并常有心绞痛发作。临床诊浙早老症合并高血压和冠心病。尸检见全身广泛动脉粥样硬化及冠状动脉粥样硬化和心肌梗塞。

Progeria (Hutchinson-Gilford syndrome) is a rare disease. A case of progeria with autopsy finding was repotted. The patient was a boy, 12 years old. Loss of hair and subcutaneous fat, atrophy of skin with pigment deposition began from 4-5 months of age, then got worse with increasing age and featured like an old man. He was found to have hypertension and coronary heart disease with frequent attacks of angina pectoris.Clinical diagnosis was progeria complicated with hypertension and coronary heart disease. Autopsy revealed wide spead atherosclerosis, severe atherosclerotic stenosis of coronary arteries and their main branches, old myocardial infarction in the anterior,posterior and lateral wall of left venlricle withscattered acute mvocardial infarction. He died of ventricular fihrillation.