急性心肌梗塞患者血浆内源性洋地黄样因子的动态变化

DYNAMIC CHANGES IN PLASMA CONCENTRATION OF ENDOGENOUS DIGITALIS-LIKE SUBSTANCE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

本文应用放射免疫分析法测定了２２例急性心肌梗塞（ＡＭＩ）患者和１８例健康人血浆内源性洋地黄样因子（ＥＤＦ）浓度。结果显示，ＡＭＩ患者第１、３、７天血浆ＥＤＦ浓度明显高于健康人（Ｐ＜０．００１及Ｐ＜０．０５），第１天开始升高，第３天升高最明显，第７天已趋于下降，第１４天大部分患者降至正常范围；ＡＭＩ组中患有高血压病或出现左心功能不全者，血浆ＥＤＦ浓度明显高于无高血压病者或左心功能正常者（Ｐ＜０．００１及Ｐ＜０．０１）。对ＡＭＩ患者血浆ＥＤＦ浓度变化的机制及意义作了初步探讨。

In this report, plasma concentration of endogenous digital-like substance(EDLS) in 22 patients with acute myocardial infarction(AMI)and 18 normal subjects were determined by radioimmunoassay. The results showed that plasma levels of EDLS in patients on the first ,third and seventh days after AMI were higher than those in normal subjects(p<0. 001 or p<0. 05);plasma level of EDLS increased on the first day after AMI, reached its peak value on the third day, began to drop on the seventh day, remained still higher on the fourteenth day but had no significant difference as compared with that in the control group(p> 0. 05).On the 14th day after AMI , the plasma level of EDIS in patients with AMI complicated by hypertension(n=9) or impaired left ventricular function(n=12) was much higher than that in 13 patients with normotension or that in 10 patients with normal left ventricular function(p<0. 001 and p<0.01, respectively). The mechanism and significance of the changes in plasma level of EDLS in patients with AMI were briefly discussed.