先天性心脏病伴肺动脉高压患者血浆心钠素水平

PLASMA ATRIAL NATRIURETIC PEPTIDE LEVELS IN PATIENTS OF CONGENITAL HEART DISEASE WITH PULMONARY ARTERY HYPERTENSION

本文采用放射性免疫分析法测定３１例先天性心脏病患者血浆心钠素水平。结果表明，先天性心脏病伴肺动脉高压患者组（２１例）血浆心钠素水平明显高于无肺动脉高压组（１０例）（Ｐ＜０．０１）及正常对照组（Ｐ＜０．０１）；血浆心钠素水平随平均肺动脉压的升高而升高（ｒ＝０．７４，Ｐ＜０．００１），术后随肺动脉压的下降而降低。结果提示，血浆心钠素水平的升高在肺动脉高压的调节中可能起着重要作用。

Plasma atrial natriuretic peptide(ANP) levels in 31 congenital heart disease patients were measured by radioimmunoassay. The results showed that plasma ANP levels in 21 cases with pulmonary artery hypertension(PAH) were significantly higher than those in 10 cases without PAH(p<0. 01) and normal controls(p<0.011. Levels of ANP increased parailelly with the severity of pulmonary artery hypertension(r=0.74, p<0.001) and decreased markedly with the drop of pulmonary artery pressure after surgery. These findings suggested that the rise in plasma ANP levels might play an important role in the regulation of pulmonary artery hypertension.