尿胰蛋白酶原-2的测定对急性胰腺炎的诊断价值

The diagnostic value of urinary trypsinogen-2 in screening acute pancreatitis

目的探讨尿胰蛋白酶原2(Trypsinogen2Try2)的测定对急性胰腺炎(AcutepancreatitisAP)的诊断价值。方法对280例急腹症患者同时测定尿Try2及血、尿淀粉酶,其中尿Try2测定采用免疫层析法,血、尿淀粉酶采用酶学方法检测。结果55例急性胰腺炎患者中有53例尿Try2阳性,敏感性为96.4%,225例非AP的急腹症患者尿Try2有12例假阳性,特异性为94.7%;而血淀粉酶的敏感性和特异性分别为81.8%(45/55)和88.9%(25/225),尿淀粉酶的敏感性和特异性分别为80.0%(44/55)和88.4%(26/225),差异有显著性(P<0.05);7例重症急性胰腺炎患者尿Try2均为阳性。结论尿Try2是急腹症患者筛选AP快速而简便的方法,具有较高的特异性和敏感性。

Objective To explore the diagnostic value of urinary trypsinogen-2 in screening acute pancreatitis.Methods In 280 acute abdominal pain patients, urinary trypsinogen-2 was tested by immunochromatography,serum and urinary amylase was detected by enzymology method.Result Urinary trypsinogen-2 was positive in 53/55 with acute pancreatitis,the sensitivity was 96.4%;12 cases with false positive were found in 225 cases without acute pancreatitis,the specificity was 96.3%.The sensitivity and specificity of serum amylase were 81.8%(45/55) and 88.9%(25/225),respectively.The sensitivity and specificity of urinary amylase were 80.0%(44/55) and 88.4%(26/225),respectively.There were statistical significances in differences of the sensitivity and specificity in above three parameters(P<0.05).Urinary trypsinogen-2 was positive in all of 7 patients with severe acute pancreatitis.Conclusion Detection of urinary trypsinogen-2 is a convenient and rapid diagnostic method with high sensitivity and specificity for screening acute pancreatitis in patients with acute abdomen.