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骨肉瘤组织中HER2、P-糖蛋白的表达与预后的关系 被引量：10

The expression of HER2 and P-gp and its prognostic significance in osteosarcoma
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摘要 大多数骨肉瘤均有HER2及P糖蛋白(P gp)的表达。P gp介导的多药耐药性(MDR)是骨肉瘤化疗不敏感的重要原因,也是影响预后的重要因素,而致癌基因HER2的表达与否则提示肿瘤恶性程度高低及转移能力的强弱。作者拟对HER2及P gp的表达及其与骨肉瘤预后的关系作一综述。 HER2 and P-gp are expressed in most of the human osteosarcoma tissue. The multidrug resistance of osteosarcoma is mediated by P-gp. The insusceptibility of human osteosarcoma to chemotherapy and the poor prognosis is correlated with the expression of P-gp. The expression of the carcinogene HER2 is a prognostic risk factor of the malignancy and metastasis of osteosarcoma. The review will narrate the expression of the HER2 and P-gp in osteosarcoma and its prognostic significance.
作者 陈志伟 吴苏稼
机构地区 南京军区南京总医院南京大学医学院临床学院骨科
出处 《医学研究生学报》 CAS 2005年第5期462-464,共3页 Journal of Medical Postgraduates
关键词 P-糖蛋白 HER2 骨肉瘤 多药耐药性 P-gp HER2 Osteosarcoma Multidrug resistance
分类号 R738.1 [医药卫生—肿瘤]
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参考文献26

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二级参考文献26

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二级引证文献58

医学研究生学报
2005年 第5期

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