免疫抑制剂治疗对肾移植患者生活质量的影响

Follow-up study with the effect of immunosuppressive regimens on patients of quality of life after renal transplantation

目的评价免疫抑制方案选择对肾移植生活质量影响。方法对肾移植患者维持免疫抑制治疗方案:霉酚酸酯+环孢素A +糖皮质激素方案和硫唑嘌呤+环孢素A +糖皮质激素方案,应用Spitzer生命质量指数评分表评价其生活质量,采用Spearman相关和逐步直线回归模型对影响因素进行分析。结果两种治疗方案比较,生活质量得分无显著差异(18. 48±2. 75vs17. 61±2. 46, P>0. 05),相关分析与逐步直线回归分析显示治疗方案与劳动和自理能力显著相关(P<0. 05);患者的年龄、教育、治疗时间及社会经济状况对其生活质量影响有显著意义(P<0. 05)。结论霉酚酸酯方案治疗效果优于硫唑嘌呤方案,但昂贵的费用与疗效的选择,应更注重社会学、经济学、伦理学相关的问题,全面改善和提高患者生活质量。

ObjectiveTo evaluate the quality of life for the patients after renal transplantation and the effect of immunosuppressive regimens. MethodsDimension of quality of life for 79 patients who received cyclosporine + Mycophenolate mofetil/azathioprine + prednisone(MMF regimen or AZA regimen)after renal transplantation were measure by Spitzer QL Index. This study was evaluated by Spearman correlation and linear regression analysis. ResultsThere are no significant in dimension of quality of life between MMF regimen and AZA regimen (18.48±2.75 versus 17.61±2.46,P>0.05). It was showed that therapy regimens were significant related to the ability of works and self-care. Also, the mean score of quality of life was correlated with age, education, longer of therapy, social and economic status (P<0.05). ConclusionCompared with the AZA, MMF regimen is better in effectiveness. Choose between costly MMF and cheaply AZA, people should pay more attention to the problems in sociality, economic and ethic.