癫痫患者的智能、记忆及认知电位P300改变

Changes of Intelligence, memory and cognitive event─related potential P300 in epileptics

对５４例癫痫患者和４８例正常人进行了神经心理测试和体感刺激诱发的事件相关电位研究。结果表明：癫痫患者可出现不同程度的智能和记忆障碍：其认知电位Ｐ３００的潜伏用与对照组相比明显延长（Ｐ＜０．００１），波幅明显降低（Ｐ＜０．００１）．总智商（ＦＩＱ）和记忆商（ＭＱ）低于正常者，Ｐ３００异常率明显升高。病程在１５年以上的患者，其智能和记忆障碍的发生率增高：Ｐ３００异常率与病程呈显著正相关（ｒ＝０．９３２，Ｐ＜０．０１）．频发组患者其智能、记忆障碍的发生率及Ｐ３００异常率均较非频发组升高（Ｐ＜０．０５）．将Ｐ３００与智能、记忆检查结合起来应用于临床，会提高检测的准确性．

Fifty─four cases of epoleptics and48 cases of healthy volunteers were subjected to a series of neu-ropsychological tests and sensory event─related potential study.The results indicated that epileptics had some degrees ofintelligence and memory disturbances. The latency of cognitive event─related potential P300in epileptics was signifi-cantly prolonged,its amplitude markedly lowered(p<0.001) as compared to the control subjects. Abnormal rate ofP300 was highly increased in epileptics with FIQ and MQ lower than normal. The incidence of intelligence and memorydisturbances increased in petients with the course of epilepsy more than 15 years; Abnormality of P300 had a significantpositive correlation with the course of epilepsy(r=0.932,p<0.01).The incidence of intelligence and memory distur-bances and abnormal P300 was significantly higher in epileptics with frequent seizure than those with infrequent seizure.Combination of P300 and intelligenec and/or memory tests in the clinical research can increase the accuracy in de-terming patient′s intelligence level.