原发性肾病综合征并发医院感染临床分析

Complicated Hospital Infection in Primary Nephrotic Syndrome:A Clinical Analysis and Methods to Prevent

目的探讨原发性肾病综合征(PNS)患者医院感染的原因和预防对策。方法对我院住院治疗的PNS患者138例,进行医院感染分析。结果138例PNS医院感染率为34. 06%,医院感染部位构成比依次为呼吸道、泌尿道、消化道;分离菌株以革兰阴性杆菌和真菌为主;血清IgG含量、住院时间、激素及免疫抑制剂与医院感染显著相关(P<0 .01)。结论加强医院感染管理,积极治疗原发病,做好疾病本身护理,合理用药,提高患者自身免疫功能,是预防医院感染的对策。

OBJECTIVE To explore the characteristics of the primary nephrotic syndrome(PNS) complicated by hospital infection and methods to prevent. METHODS Data of the patients with PNS hospitalized in our hospital from 1999 to 2002 were analyzed retrospectively. RESULTS The infection rate was 34.06% in 138 cases with PNS, hospital infections occurred mainly in the respiratory tract, urinary tract and digestive tract. Gram-negative bacilli and fungi were the dominant bacteria in the infections; the hospital infection showed close relationship with the level of IgG, stay in hospital, corticosteroid and immunosuppressive agents(P<0.01). CONCLUSIONS The hospital infection rate in PNS is 34.78%,It may be associated with the level of IgG, stay in hospital,corticosteroid and immunosuppressive agents. The main measures to prevent and treat are to strengthen the hospital infection administration, to treat actively the original disease,to use antibiotic reasonably and to increase patient′s immunologic function.