新的肾功能显像剂^（99m）锝—双半胱氨酸的临床研究

A NEW IMAGING AGENT-^(99m)Tc-EC FOR RENAL FUNCTION TEST

一个新的肾功能显像剂９９ｍ锡一双半胱氨酸（９９Ｔｃ－ＥＣ）首先在国内研制成功，并进行了临床研究。结果表明：９９ｍＴｃ－ＥＣ的肾动态显像的２０ｍｉｎ清除率明显高于９９ｍＴｃ－ＤＴＰＡ。与数字减影血管造影（ＤＳＡ）比较，其对肾血管性高血压病的诊断符合率达到９０％以上。９９ｍＴｃ－ＥＣ是一种肾小管排泌型的药物，９９ｍＴｃ－ＤＴＰＡ是肾小球过滤型药物。在临床上二者互相补充，可更好地如实反映肾脏功能的情况。

The biological behavior of 99mTechnetium-L,Lethylenedicysteine(99mTc-EC) was studied in human(n=38) and compared with 99mTechnetium-diethylenetriamine pentacetic acid(99mTc-DTPAI.99mTc-EC,being an imaging agent for tubular excretion showed a more rapid urinary excretion than 99m Tc-DTPA which is an imaging agent for glomerular filtration.The results revealed higher 20 min clearance of 99mTc-EC and the image got by which was superior than that by 99mTc-DTPA.The combined use of both agents could reflect kidney function much better.