体外循环、心脏手术的血浆血小板因子4、血小板β球蛋白浓度及血小板数的动态研究

CHANGES IN PLASMA PLATELET FACTOR4, βTHROMBOGLOBULIN AND PLATELET COUNT DURING EXTRACORPOREAL CIRCULATION FOR OPEN HEART SURGERY

本文通过对１７例先天性心脏病患者术前、术中和术后的血浆血小板因子４（ＰＦ４）、血小板β球蛋白（βＴＧ）和血小板数９个时点动态观察发现，血浆ＰＦ４浓度和βＴＧ浓度分别比术前升高１６倍和６倍，血小板数为术前４６．１％。研究表明，ＰＦ４和βＴＧ可作为体外循环中血小板激活和释放的敏感指标，对估计血小板质和量的改变有重要意义。

Plasma platelet factor 4(PF4), β-thromboglobulin (βTG), and platelet number were measured in 17 patients with congenital heart diseases at 9 predetermined points of time, including pre-, post-operation and during extracorporeal circulation (ECC). The concentrations of PF4 and βTG increased remarkably after the beginning of ECC. PF4 rose from 19. 4± 12. 7 ng/ml to 338. 9±41. 3 ng/ml, while βTG from 37. 2 ±19. 9 ng/ml to 190. 9±38. 1 ng/ml. Platelet count decreased to 46. 1 % by the end of ECC. The concentrations of PF4 and βTG positively correlated with ECC time, ECC time and βTG level negatively correlated with platelet count. We suggest that the concentrations of PF4 and βTG can be regarded as indicators to reflect the situation of platelet release during ECC for open heart surgery. Especially βTG is more useful to estimate platelet number and functions.