慢性失眠病人脑内神经递质活动的超慢涨落图表现

Abnormal neurotransmitter activation in patients with chronic insomnia

目的:探讨慢性失眠病人脑内神经递质活动变化。方法:用WF92型脑电超慢涨落分析仪,通过检测慢性失眠病人和正常人的脑电超慢涨落图(EFG),分析其谱线变化来反映脑内神经递质活动变化。结果:慢性失眠病人51例与51例健康人配对对照比较,EFG神经递质谱系S1和S2显著降低(配对t检验,P<0.01),S3、S4、S5、S7和S11两组间比较无明显差异,提示慢性失眠病人脑内神经递质谱系S1γ氨基丁酸(GABA)和S2谷氨酸(Glu)活动存在异常,S3乙酰胆碱受体(AchR)、S45羟色胺(5HT)、S5乙酰胆碱(Ach)、S7去甲肾上腺素(NE)和S11多巴胺(DA)活动无明显变化。结论:脑内神经递质GABA和Glu活动异常可能参与了慢性失眠的发病。

Objective:To investigate neurotransmitter activation in patients with chronic insomnia.Methods:Encephalofluctuogram(EFG)were obtained from 51 patients with chronic insomnia and 51 healthy individuals, Parameters of EFG that reflect neurotransmitter activation were analysed.Results:S1 and S2 of neurotransmitter list in EFG are obviously lowered in patients with chronic insomnia compared with healthy individuals.Conclusions:Neurotransmitter GABA(S1) and Glu(S2) may be involved in the patients with chronic insomnia.