复方甘草酸苷治疗慢性乙型肝炎肝纤维化疗效观察

An Observation on Curative Effects of Compound Glycyrrhizin in the Treatment of Chronic Type B Hepatitis with Hepatic Fibrosis

目的:观察复方甘草酸苷治疗慢性乙型肝炎肝纤维化的疗效。方法:146例慢性乙型肝炎肝纤维化患者应用复方甘草酸苷注射液40ml～100ml,加入5%葡萄糖注射液250ml中静脉滴注,1次/d,连用4wk,然后改为序贯疗法,即口服复方甘草酸苷片50mg,3次/d,连用3mo。结果:注射4wk、序贯治疗后总有效率分别为67.12%、81.51%(P<0.05);治疗前、后症状与体征、肝功能及肝纤维化指标比较有显著性差异(P<0.05或P<0.01)。结论:复方甘草酸苷能有效地改善肝功能,抗肝纤维化,且疗效稳定、持久。

OBJECTIVE:To observe on the curative effect of compound glycyrrhizin in the treatment of chronic hepatitis B with hepatic fibrosis.METHODS:146cases of chronic hepatitis B with hepatic fibrosis were administered by i.v.drop daily for4weeks with compound glycyrrhizin injection40ml～100ml,into which5%glucose injection(250ml)was added,then a sequential therapy was adopted in which all the patients were treated with50mg oral compound glycyrrhizin tablets3times per day for3months.RESULTS:The total effective rates after4weeks of first stage treatment and the sequential therapy were67.12%and81.51%(P<0.05)respectively.There were significant differences in the symptoms and signs,hepatic function and hepatic fibrosis indexes after treatment compared with pre-treatment(P<0.05or P<0.01).CONCLUSION:Compound glycyrrhizin can effectively improve the hepatic function and resist liver fibrosis;and its curative effect is lasting and stable.