血清免疫球蛋白水平与儿童少年血压的关系

Relationship Between Immunoglobulins and Blood Pressure in Children and Adolescents

为了解原发性高血压与机体免疫状态改变之间的因果关系，本研究应用了单向免疫扩散法对57名血压偏高儿童（血压持续高于其年龄标准的第90百分位数）及58名血压正常儿童的血清IgG，IgA和IgM水平进行了比较，结果显示，两组儿童的三种免疫球蛋白水平均无显著差异。提出在高血压病早期并不存在血清免疫球蛋白的改变，故认为血清免疫球蛋白不适于作为原发性高血压的早期识别指标。

In order to identify effect of immunological mechanism on the pathogenesis of hypertension, the serum IgG, IgA, IgM were determined in 58 mild hypertension and 57 normotensive children aged 7- 18 years by the single radial diffusion techniques. The difference were not significant between 2 groups in immunoglobulins (18. 01- 10. 53 vs. 17. 59- 8. 37 for IgG, 1. 54- 0. 84 vs. 1. 46- 0. 63 for 'IgA, 1. 11-0. 64 vs. 1. 48-0. 75mg/ml for IgM). The results indicated that the immunoglobulins were not involved in the pathogenesis of essential hypertension. So serum immunoglobulins are not suitable to be predictors of essential hypertension.