穿心莲提取物和鱼油预防粥样硬化性动脉狭窄的实验研究

EXPERIMENTAL STUDIES ON PREVENTION OF ATHEROSCLEROTIC ARTERIAL STENOSIS WITH ANDROGRAPHIS PANICULATA NEES AND FISH OIL

为寻找有效防治冠心病的药物，本文研究了中药穿心莲提取物（ＡｎｄｒｏｇｒａｐｈｉｓＰａｎｉｃｕｌａｔａＮｅｅｓ，ＡＰＮ）和鱼油对去内皮和高胆固醇饲养所诱发的兔粥样硬化性髂动脉狭窄的作用。初步结果显示，去内皮和高胆固醇饲养７周后，对照兔的髂动脉１００％均形成严重狭窄或闭塞，平均狭窄６０．５±３１．０％，加饲鱼油兔血管狭窄发生率和狭窄程度分别为７１．４％（Ｐ＜０．０５）和４９．２±２０．Ｏ％（Ｐ＜０．０５），ＡＰＮ组分别为７０％（与对照组比较，Ｐ＜０．０５）和２５．４±１０．５％（与上两组比较，Ｐ＜０．０１）。结论：本文结果提示，ＡＰＮ显著减轻实验性粥样硬化性血管狭窄，可用于冠心病的防治；鱼油亦有类似作用，但较弱。

In order to search for effective drugs to prevent and to treat coronary heart disease,we studied the effects of a Chinese herb,extract of Andrographis Paniculata Nees(APN),and fish oil(FO) on atherosclerotic iliac stenosis induced by deendothelialization and high-cholesterol diet in rabbits.Preliminary results showed that APN could significantly alleviate atherosclerotic iliac artery stenosis induced by both deendothelialization and high cholesterol diet(Control group:stenosis incidence 100%,severe stenosis 60.53±31.03%,of which 30% arteries were totally occluded;FO group:stenosis incidence and severe degree were 71% and 53.00±21.17%,respectively(vs.Control group,p<0.05),and in APN group they were 70%(vs.control group,P<0.05) and 25.39±10.52%,respectively,(vs.the above two groups,P<0.01).Preliminary results suggest that APN and FO could significantly alleviate stenosis induced by deendothelialization and high cholesterol diet,but the effesre of APN are evidently superior to FO.It is concluded that APN may play an important role in the prevention and treatment of coronary artery disease and FO is also useful.