摘要
目的探讨不同糖耐量状态下血清抵抗素(resistin)与可溶性细胞间黏附分子1(sICAM1)质量浓度的变化。方法2004-04~09在中国医科大学第一临床学院对52例2型糖尿病患者(DM组)、18例糖耐量异常(IGT)组及30例健康对照(NCT)组,采用酶联免疫分析法检测空腹血清resistin及sICAM1质量浓度;同时检测空腹血糖、胰岛素及血脂水平;并以稳态模型计算胰岛素抵抗指数(HOMAIR)。结果IGT组resistin明显高于DM组及NCT组(P均<0.05);DM和IGT组sICAM1均高于NCT组(P<0.01,P<0.05);DM组、IGT组HOMAIR明显高于NCT组(P<0.01)。结论resitin和sICAM1二者可能参与2型糖尿病的发病过程。
Objective To study the levels of serum resistin and sICAM-1 in diffferent glucose tolerance status.Methods Fasting serum resistin and sICAM-1 concentration were measured by enzyme immunoassay in 52 cases suffering from T2DM,18 cases with glucose tolerance impaired and 30 cases with normal glucose tolerance.Meanwhile,fasting blood glucose,insulin and lipids were determined.HOMA-IR was calculated.Results Fasting serum resistin concentration (ng/mL) was higher in IGT than that in those patients with T2DM and NGT (P<0.05);sICAM-1 in DM and IGT was significantly higher than that in NCT(P<0.01,P<0.05); HOMA-IR in DM and IGT was markedly higher than in NCT (P<0.01).Conclusion Resistin and sICAM-1 are correlated with HOMA-IR,which may both participate in the developwent of diabetes mellitus.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第6期510-511,共2页
Chinese Journal of Practical Internal Medicine