系统性红斑狼疮并急性胰腺炎15例临床分析

Clinical analysis of 15 cases of acute pancreatitis in systemic lupus erythematosus.

目的探讨系统性红斑狼疮(SLE)合并急性胰腺炎的临床特点、病因、发病机制和治疗方法。方法回顾性分析1983-01～2003-03北京协和医院住院治疗的SLE合并急性胰腺炎患者15例。结果急性轻型胰腺炎12例,重型胰腺炎3例。所有患者均给予中到大剂量糖皮质激素治疗,病情痊愈5例,好转5例,死亡5例。结论(1)急性胰腺炎是SLE病情活动的表现;(2)胰腺血管病变是导致胰腺炎的主要致病机制;(3)糖皮质激素可能不是导致胰腺炎的病因;(4)中到大剂量糖皮质激素治疗是安全有效的。

Objective To investigate the clinical features,causes,pathogenesis and treatment of acute pancreatitis in patients with systemic lupus erythematosus (SLE).Methods From January 1983 to March 2003,15 SLE patients with acute pancreatitis were retrospectively analyzed.Results There were 12 patients with mild acute pancreatitis and 3 patients with severe acute pancreatitis.All patients received the treatment of moderate to large dosage of corticosteroids.Five patients recovered.Five patients improved.Five patients died.Conclusion (1)Acute pancreatitis occurs in the active stage of SLE.(2)The pancreatic vascular lesion is the main pathogenic mechanism in SLE acute pancreatitis.(3)The corticosteroids may not be the cause of SLE pancreastitis.(4)The treatment with moderate to high doses of corticosteroids is safe and effective.