缺血性脑血管病患者高血压时程及相关影响因素分析

Study on the length of hypertension history and its related factors in patients with both ischemic cerebral vascular disease and hypertension.

目的研究有高血压史的缺血性脑血管病(ischemiccerebralvasculardisease,ICVD)人群中,高血压发生与ICVD发生的时程关系及影响因素。方法回顾性研究1990～1999年间解放军总医院神经内科收治的1166例首次ICVD发生之前或当时发现高血压的病人,确定高血压时程,即发现高血压至首次ICVD发生时间间隔,采用多元线性回归模型分析影响高血压时程长短的因素。结果高血压时程范围0～60(14.29±10.63)年,中位数11年。多元线性回归分析显示发现高血压年龄增长,吸烟、糖尿病使高血压时程缩短;军人的高血压时程比农民长;治疗高血压较不治疗者时程延长。结论发现高血压至首次ICVD发生的时间间隔变动较大,半数患者在发现高血压11年内发生首次ICVD,高血压与吸烟和糖尿病在导致ICVD发生的过程中具有累积效应,降压治疗能够推迟ICVD的发生。

Objective To study the length of hypertension history and its related factors in patients with both ischemic cerebral vascular disease(ICVD) and hypertension.Methods The profile of hypertension history in ICVD patients from our hospital between 1990 and 1999 was summarized.Hypertension history meant the time interval between onset of first symptomatic ICVD and establishment of diagnosis of hypertension.The related factors' influence on the length of hypertension history was analyzed by means of multiple linear regression model.Results In ICVD patients with hypertension,the mean length of hypertension history was 14.29±10.63 years,the median was 11 years.In multiple linear regression model,increased age when hypertension was diagnosed,diabetes mellitus,smoking,peasant(army man as control group) were independent factors that shortened hypertension history.Antihypertensive treatment independently lengthened hypertension history.Conclusion The length of hypertension history varies greatly,50% of patients developed the first ICVD in 11 years after the diagnosis of hypertension was established .Coexisting smoking and diabetes mellitus hasten while control of arterial blood pressure postpone onset of ICVD in patients with hypertension.