哮喘患儿血浆内皮素含量变化的临床意义

Clinical significance of the change of plasma ET-1 as related to bronchial asthma in children

目的探讨血浆内皮素(ET-1)含量变化与哮喘之间的关系。方法应用SN-682型放射免疫r仪计数仪,对50例哮喘患儿在急性期与缓解期分别测定血浆ET-1含量,并与50例正常儿童血浆ET-1含量进行对照,并同期测定血浆肿瘤坏死因子-α(TNF-α)含量。结果哮喘急性期患儿血浆ET-1含量显著高于正常儿童(P<0.01)及缓解期患儿(P<0.05)并与TNFα含量测定呈显著正相关。结论内皮素与哮喘病病情相关,是反映哮喘病病情变化一个有价值的指标。皮质激素治疗能显著降低血浆ET-1含量,可能是其抗气道炎症的作用机制之一。

Objective To study the relationship between the bronchial asthma and plasma ET-1.Methods The plasma ET-1 and plasma TNF-α of 50 bronchial asthma patients were detected with SN-682 type-immunity γ appearance counter at attack and at remission stage separately. Comparison was made between the patients and 50 healthy children.Results The plasma levels of ET-1 in the attacking stage were higher than those in the remission stage (P<0.05) and these in the patients were higher than those in the controls (P<0.01). And it showed a significant positive correlation with the plasma levels of TNF-α.Conclusion The plasma ET-1 is significantly correlated with the bronchial asthma, and it was a valuable index evaluating the progress of bronchial asthma. The adrenal cortex hormone could restrain the development of the inflammation in air tube. One mechanism may be due to its effect on the remarkable decrease of the plasma levels of ET-1.