摘要
健康志愿者10名,分别po200mm日本或国产世福素胶囊后,其体内过程符合一室模型,主要药动学参数分别为;Caxm为2.17±0.38及2.17±0.38mg·L-1;T为3.45±0.32及3.60±0.52h;Tp为4.58±0.56及4.62±0.35h;AUC为26.35±4.27及25.85±3.80mg·h-1.L-1。国产世福素胶囊与日本产世福素胶囊的相对生物利用度为99%。血浆药物浓度采用微生物法测定。
Import or domestic cefixime capsules of 200 mg dose was randomly given to 10 healthy volunteers. The concentration-time curve of cefixime can best be described with an one-compartment model, and the main parameters of the two preparations were as follows:Cmax2.17±0. 38 and 2. 17±0. 38 mg. L-1;T 3. 45±0.32 and 3. 60±0. 52 h;Tp 4.58±0.56 and 4.62±0. 35 h; AUC 26. 35±4. 27 and 25. 85 ±3. 80 mg .h-1.L-1; respectively. The plasma levels were detected withbioassay.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第1期24-26,共3页
Chinese Pharmacological Bulletin
关键词
世福素
药代动力学
生物利用度
cefixime
pharmacokinetics
bioavailability
bioassay