20—三甲基胆蒽诱发小鼠颌下腺纤维肉瘤及其超微结构的研究

Study on Mouse Submaxillary Gland Fibrosarcoma Induced by 20 methycholanthrene and its Microstructure

应用２０—三甲基胆蒽进行小鼠颌下腺肿瘤的诱发实验。实验动物２０只，其中有５只在给药第１０周后陆续发生肿瘤，观察时间为３．５个月。诱发的肿瘤光镜下由大小不等、分化不良的细胞构成，间质成份缺乏。电子显微镜下未见到上皮肿瘤细胞结合装置的桥粒连接，提示肿瘤来源于间叶组织，为纤维肉瘤。该实验为深入研究口腔颌面部纤维肉瘤提供了理想的动物模型。

wenty mice were used to study submaxillary gland tumor induced by 20 methylcholanthren andobserved for 3. 5 months.The tumor was founed in 5 mice in 10 weeks.Microscopically,the inducedtumor consisted of f1broid or spidle cells which were lower differentiation and absence of mesenchyme.Under electro microscope,intercellular bridges like epithelial tumor were not found,which indicatedthe tumor was fibrosarcoma originating from mesenchymal tissues,The experiment provides an animalmodel for researching fibrosarcoma of oral maxillofacial region.